Bio-Chemistry (M.Phil./Ph.D.) 2018 Panjab University Entrance Exam With Answers

Prepare for Bio-Chem M.Phil./Ph.D. Panjab Univ. Entrance with Jetty Study. MCQ format, including answers. Boost your readiness now!

1. Similarities in the structure and function of two proteins indicate that they are members of a family that share a common ancestor. If they are from different species, they are called-

2. Which of the following statements about the active site of an enzyme is correct?

3. Which of the following statements about isoeletric focusing is correct?

4. Which of the following statements about membrane fluidity is correct?

5. Insulin and glucagon are two major hormones that regulate carbohydrate metabolism. Which of the following statements correctly explains their action ?

6. Which of the following statements about the enzyme lactate dehydrogenase is correct?

7. During fatty acid synthesis, acetyl groups are transported from the mitochondrion to the cytosol as-

8. Which of the following reasons does not apply for conversion of proto-oncogene to oncogene ?

9. Which of the following method is extensively used for obtaining pluripotent stem cells for somatic cell gene therapy?

10. In an α-helical polypeptide, the backbone Hydrogen bonds are between-

11. Proofreading activity of DNA polymerase III corrects errors during replication by recognizing incorrect bases at-

12. Cystic fibrosis is a disease which is caused by a mutation in cystic fibrosis transmembrane conductance regulator(CFTR). CFTR is involved in the transport of which of the following ions-

13. The regulation of transcription allows a bacterial cells to adapt to a changing environment. Which of the subunits of RNA polymerase is the regulatory subunit?

14. Collagen, an important extracellular matrix protein, requires post translational hydroxylation for strengthening its triple helix structure. Which of the vitamin is required for this essential hydroxylation reaction ?

15. What is the smallest number of molecules of ATP and GTP consumed in the synthesis of a 50 residue peptide chain, starting from precursor amino acids. Assume that hydrolysis of PPi is equivalent to the hydrolysis of ATP for this calculation.

16. Which one of the following methods is most suitable for monitoring the alterations in the levels of a serum protein using an antibody ?

17. Lectins are used to identify the blood type in a clinical setting. Which motif does it recognize and bind?

18. Which one of the following combinations must be present in a steroid receptor that is located in the cytoplasm?

19. What is the function of p53 which prevents the development of cancer?

20. Which of the following signals is not coupled to G protein related signal transduction pathway ?

21. A PCR reaction that continues for 30 cycles will produce approximately how many PCR products from a single template DNA molecule?

22. In an experiment to identify the post-translational modification of a protein, following experimental data was obtained.

23. Which of the following class of antibodies is involved in Type I hypersensitivity reaction?

24. A deletion of three consecutive bases in the coding region of a gene cannot result in-

25. Which of the following enzymes does not require a primer:

26. Zn is an essential cofactor for :

27. Citrate has a positive allostearic effect on which one of the following-

28. The human genome project began as researchers mapped ------ and sites of cytogenetic

29. The catalytic efficiency of two enzymes can be compared by-

30. Which of the following statements about the competitive inhibition of an enzyme- catalyzed reaction is correct?

31. Which of the following statements about Western Blotting is correct?

32. Which of the following statements about the mechanism of the Na+/K+ pump is correct?

33. Which of the following statements about food storage in the body is correct?

34. Which of the following statements about prostaglandins is NOT correct?

35. A protein has one Tryptophan and two Tyrosine residues. What would be the molar concentration of the protein if its absorbance at 280nm is 1.6 { Extinction coefficient of Trp residue is 5000M-1cm-1 and for Tyr- 1500 M-1cm-1}.

36. Koshland’s theory of enzyme action is called-

37. ollowing is the general structure of a glycerophospholipid. What is the common name of the phospholipid if X is replaced by choline-

38. Phenylketonuria occurs due to deficiency of the enzyme:

39. Which of the following would have high content of triglycerides?

40. You have to determine the amino acid sequence of a peptide. You perform the following steps using enzyme cleavage of your peptide (see table below):

41. Tumor cells have a higher requirement for glutamine. Which out of the following is NOT an appropriate reason for this metabolic pattern?

42. The first reaction in the degradation of the majority of amino acids involves the participation of which of the following enzymes-

43. A 25 year old man undertakes a prolonged fast for religious reasons. Which of the following metabolites will be elevated in his blood plasma after 24 hrs?

44. Allopurinol, a drug for the treatment of Gout, is a--------- inhibitor of xanthine oxidase.

45. Which of the following features of mature mRNA is thought to protect it against degradation?

46. Select the one FALSE statement.

47. Phase II reaction of xenobiotic metabolism include all of the following except-

48. Which of the following statements do not apply to Puromycin?

49. Which of the following groups of enzymes are unique to the Calvin cycle?