Biology : PU-CET (U.G) 2017 Panjab University Entrance Exam With Answers

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39.

The Cofactor Essential For The Catalytic Activity Of Carboxypeptidase Enzyme Is :

A: Fe++
B: Mn++
C: Mg++
D: Zn++

The answer is: D

Explanation

The correct answer is D: Zn++.

Zinc ion (Zn++) is the cofactor essential for the catalytic activity of carboxypeptidase enzyme. Carboxypeptidase is an enzyme that cleaves the terminal peptide bond from the carboxy end of a peptide chain, resulting in the release of a single amino acid. This enzyme requires Zn++ ion as a cofactor to catalyze the hydrolysis reaction. The Zn++ ion binds to the enzyme and plays a critical role in stabilizing the transition state of the reaction, lowering the activation energy and increasing the rate of the reaction.