M.Sc. Bio-Chemistry (PU-CET P.G) 2017 Panjab University Entrance Exam With Answers

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31.

Statins are very effective against hypercholesterolemia, a major cause of atherosclerosis. These drugs reduce plasma cholesterol levels by

A: Preventing absorption of cholesterol from the intestine.
B: Increasing the excretion of cholesterol from the body via conversion to bile acids.
C: Inhibiting the conversion of 3-hydroxy-3-methylglutaryl-CoA to mevalonate in the pathway for cholesterol biosynthesis.
D: Increasing the rate of degradation of 3-hydroxy-3-methylglutaryl CoA reductase.

The answer is: C

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