Explanation
Tissue macrophages are mature D: Monocytes.
Monocytes are a type of white blood cell produced in the bone marrow and are an important part of the immune system. They circulate in the bloodstream for a short period before they migrate into the tissues, where they differentiate into tissue macrophages.
Macrophages are specialized immune cells that are involved in many different functions, including phagocytosis (ingestion) of foreign particles, antigen presentation, and cytokine production. They play a critical role in the immune response to infections and are found in nearly all tissues of the body.
Once monocytes migrate into tissues, they mature into macrophages and take on specific functions based on the tissue they reside in. For example, macrophages in the liver are called Kupffer cells, and those in the brain are called microglia.